Program

Download the iCSD2023 program here (PDF).

DAY 1, OCTOBER 2, MONDAY
15:00-18:00Registration
16:00-18:00Introduction to SD: pertinent issues (questions and answers)
Chair: Bill Shuttleworth
18:00-20:00Reception
DAY 2, OCTOBER 3, TUESDAY
8:00-9:00Registration
8:30-9:00Opening remarks
Eszter Farkas, Tony Strong
9:00-10:00Keynote lecture I
Chair: Martin Lauritzen
Microglia modulate neuro-vascular interactions in the brain via purinergic mechanisms and shape central inflammatory responses
Ádám Dénes
10:00-11:00Oral session I: SD in ischemic and hemorrhagic stroke
Chair: Jens Dreier
10:00-10:20[O1] Spreading depolarization is a biomarker for infarct growth in malignant stroke
Christina M. Kowoll, Leonie Schumm, Simeon OA Helgers, Patrick Dömer, Alexandra Gieffers, Coline L. Lemale, Sebastian Major, Christian Dohmen, Gereon R. Fink, Gerrit Brinker, Tilmann von Pidoll, Jens P. Dreier, Nils Hecht, Johannes Woitzik
10:20-10:40[O2] Loss of cerebral autoregulation during Spreading Depolarization in a translational model and a clinical study of hemorrhagic stroke
Francisco Leonardo Ramírez-Cuapio, Renan Sánchez-Porras, Modar Kentar, Pablo Albiña-Palmarola, Roberto Díaz-Peregrino, Jens P. Dreier, Johannes Woitzik, Edgar Santos
10:40-11:00[O3] Spreading depolarization following ischemic stroke triggers unique neuronal calcium dynamics and behaviour in freely behaving female mice
Andrew K.J. Boyce, Yannick Fouad, Cristina Martins-Silva, Renaud Gom, Leo Molina, Tamás Füzesi, Carina Ens, G. Campbell Teskey, Wilten Nicola, Roger J. Thompson
11:00-11:30Coffee break
11:30-12:30Oral session II: SD and cerebral metabolism
Chair: Britta Lindquist
11:30-11:50[O4] Tissue partial pressure of oxygen during spreading depolarization in malignant stroke is associated with outcome
Nils Hecht, Daisy Haddad, Leoni Schumm, Nora Dengler, Patrick Dömer, Max Schrammel, Franziska Meinert, Sebastian Major, Coline Lemale, Jens Dreier, Peter Vajkoczy, Johannes Woitzik
11:50-12:10[O5] Long-term effects of spreading depolarizations on collateral vessel growth and hemodynamic impairment after experimental chronic hypoperfusion in mice
Annika Köhne, Patrick Dömer, Simeon OA Helgers, Franziska Meinert, Renán Sánchez-Porras, Johannes Woitzik
12:10-12:30[O6] Brain glycogen stores recruitment supports tissue repolarization after spreading depolarizations
Shuting Chen, Baptiste Balança, and Stephane Marinesco
12:30-13:30Lunch
13:30-14:50Oral session III: SD in cerebrovascular and traumatic brain injury states
Chair: Edgar Santos
13:30-13:50[O7] Spreading depolarizations occur after cerebral venous sinus occlusion in the gyrencephalic brain
Renan Sanchez-Porras, Francisco. L. Ramirez-Cuapio, Mildred A. Gutierrez-Herrera, Pablo Albiña-Palmarola, Juan M. Lopez-Navarro, Marcos Suarez-Gutierrez, Roberto Diaz-Peregrino, Diego A. Sandoval-Lopez, Modar Kentar, Johannes Woitzik, Edgar Santos
13:50-14:10[O8] A novel model to study spreading depolarizations under cerebral hypoperfusion in the gyrencephalic brain
Lars Wessels, Sebastian Major, Agustin Liotta, Patrick Dömer, Johannes Woitzik, Jens Dreier, Nils Hecht
14:10-14:30[O9] Memantine Inhibits Cortical Spreading Depolarizations and Improves Outcome of Repetitive Mild Traumatic Brain Injury
J. Muradov, M. MacLean, L. Wu, A. Friedman
14:30-14:50[O10] Multivariate Modeling of Intensive Care Risk Factors for Spreading Depolarizations in Severe Traumatic Brain Injury
Jed A. Hartings, Xinyu Cong, Brandon Foreman, and Roman Jandarov
14:50-15:20Coffee break
15:20-16:20Poster Power Pitch
Chair: Eszter Farkas
16:20-17:20Poster Session I
[P1] An in vivo, non-invasive platform to study the impact of repetitive Spreading Depolarisation in awake head fixed mice
Kağan Ağan, Neela K. Codadu, Daman Rathore, Eduard Masvidal-Codina, Enrique Fernández-Serra, Randy Gyimah, Anton Guimera-Brunet, Rob C. Wykes
[P2] Occurrence of Spreading Depolarization and impact on delayed infarct progression after malignant hemispheric stroke in C57/bl6 mice
Anna Zdunczyk, Leonie Schumm, Simeon OA Helgers, Patrick Dömer, Annika Köhne, Xi Bai, Sebastian Major, Jens Dreier, Peter Vajkoczy, Johannes Woitzik
[P3] Frequency band changes during ischemic stroke, spreading depolarizations and mild hypothermia in gyrencephalic brains
Roberto Díaz-Peregrino, Modar Kentar, Carlos Trenado, Renán Sánchez-Porras, Pablo Albiña-Palmarola, Johannes Woitzik, Edgar Santos
[P4] Reperfusion failure after spreading depolarization shapes hemoglobin content in the mouse cortex
Anna Törteli, Armand Rafael Bálint, Réka Tóth, Péter Makra, Ferenc Bari, Eszter Farkas, Ákos Menyhárt
[P5] Isoflurane improves cerebral oxygenation during spreading depolarization by lowering the cerebral metabolic rate of oxygen in vitro
Karl Schoknecht, Mathilde Maechler, Iwona Wallach, Jens P. Dreier, Agustin Liotta, Nikolaus Berndt
[P6] Cortical spreading depolarization scalp-brain voltage ratios and images from simulated concussion and subarachnoid hemorrhage
Samuel J. Hund, Benjamin R. Brown, Coline L. Lemale, Prahlad G. Menon, Kirk A. Easley, Jens P. Dreier, Stephen C. Jones
[P7] Cold Spreading Depolarization (`cold-SD`) in Rodent Brain Slices
Dominique Hancock, Edwin Kiarie, Peter Gagolewicz Victoria Donovan, R. David Andrew
[P8] Diversity of cortical activity changes beyond depression during Spreading Depolarizations
Azat Nasretdinov, Daria Vinokurova, Coline Lemale, Gulshat Burkhanova-Zakirova, Ksenia Chernova, Julia Makarova, Oscar Herreras, Jens P. Dreier, Roustem Khazipov
DAY 3, OCTOBER 4, WEDNESDAY
9:00-10:00Keynote lecture II
Chair: Cenk Ayata
Exploring the Monogenic Borderland of Epilepsy and Spreading Depolarization
Jeffrey Noebels
10:00-11:00Oral session IV: Interplay between SD and seizures
Chair: Rob Wykes
10:00-10:20[O11] Characterizing the spatiotemporal patterns of ictal spreading depressions
Elliot H Smith, Tyler S Davis, KC Brennan, John D Rolston, Punam Sawant-Pokam
10:20-10:40[O12] The astrocyte potassium channel Kir4.1 influences seizure and spreading depolarisation susceptibility
Neela K. Codadu, Eduard Masvidal-Codina, Enrique Fernández-Serra, Randy Gyimah, Hasna A. Boumenar, Yunan Gao, Anton Guimera-Brunet, Rob C. Wykes
10:40-11:00[O13] Intravital imaging reveals calcium depletion in the endoplasmic reticulum during cortical spreading depressions following generalized seizures in mice
Matthew A. Stern, Ken Berglund, Eric R. Cole, Robert E. Gross
11:00-11:30Coffee break
11:30-12:30Oral session V: Neuronal excitability and network activity in the wake of SD
Chair: Daniela Pietrobon
11:30-11:50[O14] Changes in the Direct Cortical Response during spreading depolarisations in the injured human brain
Sharon Jewell, Tomas Watanabe, Jose-Pedro Lavrador, Sascha Freigang, Prajwal Ghimire, Christos Tolias, Clemens Pahl, Martyn Boutelle, Anthony Strong
11:50-12:10[O15] A novel local regression approach to analyze functional connectivity following CSD
Miran Öncel, James H Lai, Sanem A Aykan, Joanna Yang, Tao Qin, Andreia Morais, Andrea Harriott, Sava Sakadžić, Cenk Ayata, David Y Chung
12:10-12:30[O16] Voltage-gated calcium channels and glutamate NMDA receptors are both necessary for initiation of cortical spreading depression
Marina Vitale, Angelita Tottene, Maral Zarin Zadeh, KC Brennan, Daniela Pietrobon
12:30-13:30Lunch
13:30-14:50Oral session VI: SD inhibition – the therapeutic benefit of ketamine and nimodipine
Chair: Martin Fabricius
13:30-13:50[O17] S-ketamine for cortical spreading depolarization in patients with severe acute brain injury (KETA-BID): protocol for a randomised, blinded pilot trial
Trine Hjorslev Andreasen, Markus Harboe Olsen, Christian Gluud, Jane Lindschou, Martin Fabricius, Kirsten Møller
13:50-14:10[O18] Mapping Ketamine Modulation of Spreading Depolarisation and Regional Blood Flow Post-Stroke Using Graphene Micro-Transistor Arrays
Samuel M. Flaherty, A. Eladly, K. Hills, J. Merlini, E. Masvidal-Codina, E. Fernandez, X. Illa, E. Prats-Alfonso, K. Kostarelos, S Allan, J.A. Garrido, A. Guimerà-Brunet, R.C. Wykes
14:10-14:30[O19] Nimodipine is protective against spreading depolarization and neuroinflammation
Rita Frank, István Pesti, Péter Archibald Szarvas, Ákos Menyhárt, Ferenc Bari, Eszter Farkas
14:30-14:50[O20] Nimodipine accelerates the restoration of neurovascular coupling after spreading depolarization
Ákos Menyhárt, Ferenc Bari, Eszter Farkas
14:50-15:20Coffee break
15:20-16:20Poster Session II
[P9] Ca2+-dependent modulation of astrocytic gap junctional coupling upon brief metabolic stress
Sara Eitelmann, Katharina Everaerts, Laura Petersilie, Christine Rosemarie Rose* & Jonathan Stephan
[P10] Blockade of calmodulin-dependent AQP4 trafficking restores neurovascular coupling after stroke and enhances the spreading depolarization coupled hyperemia in mice
Réka Tóth, Ákos Menyhárt, Eszter Farkas
[P11] Red Flags for Symptoms of Secondary Spreading Depression in Clinical Practice: SNAIL
Anders Hougaard
[P12] The effects of an NO donor on the SD-induced negative ultraslow potential (NUP) after proximal cerebral artery occlusion (PCAO) in rats
Coline L. Lemale, Baptiste Balança, Sara Simula, Sebastian Major, Jens P. Dreier
[P13] Modulation of propagation of cortical spreading depolarization by GABAergic neurons
Hadi Srour, Martina Simonti, Massimo Mantegazza
[P14] The impact of the novel sigma-1 receptor agonist S-0758 on somatosensory stimulation and spreading depolarization in cerebral ischemia
Szilvia Kecskés, Írisz Szabó, Ákos Menyhárt, Eszter Farkas
[P15] Electrical signaling at the endothelial cell pericyte syncytium during recurrent seizures
Mirja Grote Lambers, Henrike Planert, Majed Kikhia, Agustin Liotta, Christian Madry, Jörg RP Geiger, Richard Kovács
16:30-18:30Social program: Guided city tour or Bird watching
20:00-22:00Networking Dinner
Presentation of the Young Investigator Award in poster category
Ferenc Bari (Hungarian Physiological Society)
DAY 4, OCTOBER 5, THURSDAY
9:00-10:00Keynote lecture III
Chair: Jed Hartings
You Can’t Unsee It
Andrew Carlson
10:00-11:00Oral session VII: Tissue susceptibility for SD: novel mechanisms
Chair: Sharon Jewel
10:00-10:20[O21] Spreading depolarization induced plasticity is mediated by a combined potentiation of both AMPAR- and NMDAR- mediated components of the fEPSP
Jordan E. Weisend, Andrew P. Carlson, Bill Shuttleworth
10:20-10:40[O22] Demonstrating Brain Release of an Activator of Spreading Depolarization
Hellas Julia, Gagolewicz Peter J, Lee Kelly, Ollen-Bittle Nikita, Andrew R David
10:40-11:00[O23] Investigating seizure and spreading depolarisation susceptibility in a model of glioblastoma-related epilepsy using graphene-based epidural probes
Kate Hills, Samuel Flaherty, Aralolaoluwa Ogunrin, Daman Rathore, Neela Codadu, Eduard Masvidal Codina, Enrique Fernandez, Xavi Illa, Thomas Kisby, Anton Guimera Brunet, Kostas Kostarelos, Rob C Wykes
11:00-11:30Coffee break
11:30-12:30Oral session VIII: Clinical and experimental SD detection: models and methods
Chair: Baptiste Balança
11:30-11:50[O24] Towards noninvasive, automated detection and parameter estimation of spreading depolarizations in patients with intact skull using scalp EEG
Alireza Chamanzar, Han Yi Wang, Jonathan Elmer, Lori Shutter, Jed Hartings, Aman B. Patel, Christopher J. Stapleton, David Y. Chung, Eric S. Rosenthal, Pulkit Grover
11:50-12:10[O25] Electrocortical activity of the porcine brain during cardiac arrest, resuscitation and return of spontaneous circulation
Alois Schiefecker, G. Putzer, M. Kofler, L. Putnina, J. Wagner, P. Spraider, S. Mathis, J. Abram, D. Pinggera, M. Bauer, B. Glodny, J. Martini, R. Helbok
12:10-12:30[O26] A novel platform to investigate seizure and spreading depolarisation interactions using calcium imaging and graphene micro-transistor arrays
Daman Rathore, Smith A, Masvidal-Codina E, Fernandez-Serra E, Rossi LF, Guimera-Brunet A, Timofeeva Y, Wykes RC, Volynski KE
12:45-13:00Presentation of the Young Investigator Award in oral category
Eszter Farkas (Hungarian Physiological Society)
Presentation of iCSD 2024
Cenk Ayata
Closing remarks
Program Committee Members