Research papers
2024
- Pesti, I., Légrádi, Á., & Farkas, E. (2024). Primary microglia cell cultures in translational research: Strengths and limitations. Journal of Biotechnology, 386, 10–18. Advance online publication.
Open access - Dulka K, Lajkó N, Nacsa K, Gulya K. (2024) Opposite and Differently Altered Postmortem Changes in H3 and H3K9me3 Patterns in the Rat Frontal Cortex and Hippocampus. Epigenomes. 2024; 8(1):11.
Open access
2023
- Zhou Z, Wang D, Luo D, Zhou Z, Liu W, Zeng W, Dinnyés A, Xiong YL, Sun Q. (2023) Non-covalent binding of chlorogenic acid to myofibrillar protein improved its bio-functionality properties and metabolic fate. Food Chem. 2024. 440:138208. doi: 10.1016/j.foodchem.2023.138208. Epub ahead of print.
Open access - Farkas, E., Frank, R., Menyhárt, Á. (2023) The contribution of astrocytes to ischemia-related cerebral edema formation and increased neuronal excitability. Glia, 71(S1), pp. E92.
Open access - Frank, R., Farkas, E., Menyhárt, Á. (2023) The role of astrocyte dysfunction in the evolution of spreading depolarization during ischemia. Glia, 71(S1), pp. E669.
Open access - Frank, R., Pesti, I. Menyhárt, Á., Szarvas, P., Gulya, K., Bari, F., Farkas, E. (2023) Nimodipine exerts a protective effect against spreading depolarization and neuroinflammation. Physiology, 38(S1), doi: 10.1152/physiol.2023.38.S1.5762940.
Open access - Törteli, A., Bálint, A.R., Tóth, R., Makra, P., Bari, F., Farkas, E., Menyhárt, Á. (2023) Reperfusion failure after spreading depolarization shapes hemoglobin content in the mouse cortex. IBRO Neuroscience Reports, 15, S467-S867, P1300 / #4102.
Open access - Tóth, R., Kovács, N., Horváth, I., Máthé, D., Menyhárt, Á., Farkas, E. (2023) Infarct size in the subacute phase of experimental focal ischemic stroke does not correspond with functional outcomes. J. Cereb. Blood Flow Metab., 43(1S), S122
Open acccess - Bari, F., Bálint, A.R., Menyhárt, Á., Farkas, E. (2023) Spreading depolarization impairs neurovascular coupling in ischemia/reperfusion in mice. J. Cereb. Blood Flow Metab., 43(1S), S30
Open acccess - Ballók B, Schranc Á, Tóth I, Somogyi P, Tolnai J, Peták F, Fodor GH. Comparison of the respiratory effects of commonly utilized general anaesthesia regimes in male Sprague-Dawley rats. Front Physiol. 2023 Sep 18;14:1249127. doi: 10.3389/fphys.2023.1249127.
Open access - Horánszky A, Shashikadze B, Elkhateib R, Lombardo SD, Lamberto F, Zana M, Menche J, Fröhlich T, Dinnyés A. Proteomics and disease network associations evaluation of environmentally relevant Bisphenol A concentrations in a human 3D neural stem cell model. Front. Cell Dev. Biol., 16 August 2023 doi: 10.3389/fcell.2023.1236243
Open access - Lamberto F, Shashikadze B, Elkhateib R, Lombardo SD, Horánszky A, Balogh A, Kistamás K, Zana M, Menche J, Fröhlich T, Dinnyés A. Low-dose Bisphenol A exposure alters the functionality and cellular environment in a human cardiomyocyte model. Environ Pollut. 2023 Aug doi: 10.1016/j.envpol.2023.122359.
Open Access - Kiss T, Mir Y, Stefancsik G, Ganbat G, Askarova A, Monostori E, Dulka K, Szebeni GJ, Nyúl-Tóth Á, Csiszár A, Legradi A. Galectin-1 as a marker for microglia activation in the aging brain. Brain Res. 2023 Aug 7 doi: 10.1016/j.brainres.2023.148517.
Open Access - Kistamás K, Müller A, Muenthaisong S, Lamberto F, Zana M, Dulac M, Leal F, Maziz A, Costa P, Bernotiene E, Bergaud C, Dinnyés A. (2023) Multifactorial approaches to enhance maturation of human iPSC-derived cardiomyocytes. J. Mol. Liq. doi:10.1016/j.molliq.2023.122668.
Open Access - Szabo M, Lajkó N, Dulka K, Barczánfalvi G, Lőrinczi B, Szatmári I, Mihály A, Vécsei L, Gulya K. (2023) The kynurenic acid analog SZR104 induces cytomorphological changes associated with the anti-inflammatory phenotype in cultured microglia. Sci Rep. 2023 Jul 13 doi: 10.1038/s41598-023-38107-8.
Open access - Zhou Z, Luo D, Li M, Lao G, Zhou Z, Dinnyés A, Xu W, Sun Q. (2023) A Novel Multicellular Placental Barrier Model to Investigate the Effect of Maternal Aflatoxin B1 Exposure on Fetal-Side Neural Stem Cells. Toxins. doi: 10.3390/toxins15050312
Open access - Kecskés, Sz.,Menyhárt, Á., Bari, F., Farkas, E. (2023) Nimodipine augments cerebrovascular reactivity in aging but runs the risk of local perfusion reduction in acute cerebral ischemia. Front Aging Neurosci. doi: 10.3389/fnagi.2023.11752801.
Open access - Menyhárt, Á., Bálint, A. R., Kozák, P., Bari, F., & Farkas, E. (2023). Nimodipine accelerates the restoration of functional hyperemia during spreading oligemia. J Neurochem. 2023 Feb 22. doi: 10.1111/jnc.15792.
Open access - Törteli, A., Tóth, R., Berger, S., Samardzic, S., Bari, F., Menyhárt, Á., & Farkas, E. (2023). Spreading depolarization causes reperfusion failure after cerebral ischemia. J Cereb Blood Flow Metab. 2023 Jan 26:271678X231153745. doi: 10.1177/0271678X231153745.
Open access - Zhou, Z., Wang, D., Xu, X., Dai, J., Lao, G., Zhang, S., Xu, X., Dinnyés, A., Xiong, Y., & Sun, Q. (2023). Myofibrillar protein-chlorogenic acid complexes ameliorate glucose metabolism via modulating gut microbiota in a type 2 diabetic rat model. Food Chemistry, 409, 135195. doi:10.1016/j.foodchem.2022.135195.
Open access
2022
- Hojeij, B., Rousian, M., Sinclair, K. D., Dinnyes, A., Steegers-Theunissen, R. P. M., & Schoenmakers, S. (2022). Periconceptional biomarkers for maternal obesity: a systematic review. Reviews in Endocrine & Metabolic Disorders, doi: 10.1007/s11154-022-09762-5
Open access - Tian, L., Zhao, R., Xu, X., Zhou, Z., Xu, X., Luo, D., Zhou, Z., Liu, Y., Kushmaro, A., Marks, R. S., Dinnyés, A., & Sun, Q. (2022). Modulatory effects of Lactiplantibacillus plantarum on chronic metabolic diseases. Food Science and Human Wellness, 12(4), 959–974. doi: 10.1016/j.fshw.2022.10.018
Open access - Kovács T, Szinyákovics J, Billes V, Murányi G, Varga VB, Bjelik A, Légrádi Á, Szabó M, Sándor S, Kubinyi E, Szekeres-Paracky C, Szocsics P, Lőke J, Mulder J, Gulyás B, Renner É, Palkovits M, Gulya K, Maglóczky Z, Vellai T. A conserved MTMR lipid phosphatase increasingly suppresses autophagy in brain neurons during aging. Sci Rep. 2022 Dec 17;12(1):21817. doi: 10.1038/s41598-022-24843-w.
Open access - Kata D, Gróf I, Hoyk Z, Ducza E, Deli MA, Zupkó I, Földesi I. Immunofluorescent Evidence for Nuclear Localization of Aromatase in Astrocytes in the Rat Central Nervous System. Int J Mol Sci. 2022 Aug 11;23(16):8946. doi: 10.3390/ijms23168946.
Open access - Fehér A, Schnúr A, Muenthaisong S, Bellák T, Ayaydin F, Várady G, Kemter E, Wolf E, Dinnyés A. Establishment and characterization of a novel human induced pluripotent stem cell line stably expressing the iRFP720 reporter. Sci Rep. 2022 Jun 14;12(1):9874. doi: 10.1038/s41598-022-12956-1.
Open access - Menyhárt Á, Frank R, Farkas AE, Süle Z, Varga VÉ, Nyúl-Tóth Á, Meiller A, Ivánkovits-Kiss O, Lemale CL, Szabó Í, Tóth R, Zölei-Szénási D, Woitzik J, Marinesco S, Krizbai IA, Bari F, Dreier JP, Farkas E.Malignant astrocyte swelling and impaired glutamate clearance drive the expansion of injurious spreading depolarization foci.J Cereb Blood Flow Metab. 2022 Apr;42(4):584-599. doi: 10.1177/0271678X211040056.
Open access - Abdelghafour MM, Orbán Á, Deák Á, Lamch Ł, Frank É, Nagy R, Ziegenheim S, Sipos P, Farkas E, Bari F, Janovák L. Biocompatible poly(ethylene succinate) polyester with molecular weight dependent drug release properties. Int J Pharm. 2022 Mar 9:121653. doi: 10.1016/j.ijpharm.2022.121653
Open access - Andrew RD, Hartings JA, Ayata C, Brennan KC, Dawson-Scully KD, Farkas E, Herreras O, Kirov SA, Müller M, Ollen-Bittle N, Reiffurth C, Revah O, Robertson RM, Shuttleworth CW, Ullah G, Dreier JP. The Critical Role of Spreading Depolarizations in Early Brain Injury: Consensus and Contention. Neurocrit Care. 2022 Mar 7. doi: 10.1007/s12028-021-01431-w
Open access - Császár E, Lénárt N, Cserép C, Környei Z, Fekete R, Pósfai B, Balázsfi D, Hangya B, Schwarcz AD, Szabadits E, Szöllősi D, Szigeti K, Máthé D, West BL, Sviatkó K, Brás AR, Mariani JC, Kliewer A, Lenkei Z, Hricisák L, Benyó Z, Baranyi M, Sperlágh B, Menyhárt Á, Farkas E, Dénes Á. Microglia modulate blood flow, neurovascular coupling, and hypoperfusion via purinergic actions. J Exp Med. 2022 Mar 7;219(3):e20211071. doi: 10.1084/jem.20211071.
Open access - Andrew RD, Farkas E, Hartings JA, Brennan KC, Herreras O, Müller M, Kirov SA, Ayata C, Ollen-Bittle N, Reiffurth C, Revah O, Robertson RM, Dawson-Scully KD, Ullah G, Dreier JP. Questioning Glutamate Excitotoxicity in Acute Brain Damage: The Importance of Spreading Depolarization. Neurocrit Care. 2022 Feb 22. doi: 10.1007/s12028-021-01429-4.
Open access - Nunes C, Singh P, Mazidi Z, Murphy C, Bourguignon A, Wellens S, Chandrasekaran V, Ghosh S, Zana M, Pamies D, Thomas A, Verfaillie C, Culot M, Dinnyes A, Hardy B, Wilmes A, Jennings P, Grillari R, Grillari J, Zurich MG, Exner T. An in vitro strategy using multiple human induced pluripotent stem cell-derived models to assess the toxicity of chemicals: A case study on paraquat. Toxicol In Vitro. 2022 Feb 16:105333. doi: 10.1016/j.tiv.2022.105333
Open access - Szabo M, Lajkó N, Dulka K, Szatmári I, Fülöp F, Mihály A, Vécsei L, Gulya K. Kynurenic Acid and Its Analog SZR104 Exhibit Strong Antiinflammatory Effects and Alter the Intracellular Distribution and Methylation Patterns of H3 Histones in Immunochallenged Microglia-Enriched Cultures of Newborn Rat Brains. International Journal of Molecular Sciences. 2022; 23(3):1079. doi: 10.3390/ijms23031079
Open access - Mitrečić D, Hribljan V, Jagečić D, Isaković J, Lamberto F, Horánszky A, Zana M, Foldes G, Zavan B, Pivoriūnas A, Martinez S, Mazzini L, Radenovic L, Milasin J, Chachques JC, Buzanska L, Song MS, Dinnyés A. Regenerative Neurology and Regenerative Cardiology: Shared Hurdles and Achievements. International Journal of Molecular Sciences. 2022; 23(2):855. doi:10.3390/ijms23020855
Open access - Francistiová L, Vörös K, Lovász Zs, Dinnyés A, and Kobolák J. Detection and Functional Evaluation of the P2X7 Receptor in HiPSC Derived Neurons and Microglia-Like Cells. Frontiers in Molecular Neuroscience 14, no. January (2022): 1–16. doi: 10.3389/fnmol.2021.793769.
Open access - Menyhárt Á, Varga DP, M Tóth O, Makra P, Bari F, Farkas E. Transient Hypoperfusion to Ischemic/Anoxic Spreading Depolarization is Related to Autoregulatory Failure in the Rat Cerebral Cortex. Neurocrit Care. 2022 Jun doi: 10.1007/s12028-021-01393-z.
Open access
2021
- Horánszky A, Becker JL, Zana M, Ferguson-Smith AC, Dinnyés A. Epigenetic Mechanisms of ART-Related Imprinting Disorders: Lessons From iPSC and Mouse Models. Genes. 2021; 12(11):1704. doi: 10.3390/genes12111704.
Open access - Rubini E, Baijens IMM, Horánszky A, Schoenmakers S, Sinclair KD, Zana M, Dinnyés A, Steegers-Theunissen RPM, Rousian M. Maternal One-Carbon Metabolism during the Periconceptional Period and Human Foetal Brain Growth: A Systematic Review. Genes (Basel). 2021 Oct 17;12(10):1634. doi: 10.3390/genes12101634.
Open access - Lamberto F, Peral-Sanchez I, Muenthaisong S, Zana M, Willaime-Morawek S, Dinnyés A. Environmental Alterations during Embryonic Development: Studying the Impact of Stressors on Pluripotent Stem Cell-Derived Cardiomyocytes. Genes (Basel). 2021 Sep 30;12(10):1564. doi: 10.3390/genes12101564.
Open access - Abdelghafour MM, Orbán Á, Deák Á, Lamch Ł, Frank É, Nagy R, Ádám A, Sipos P, Farkas E, Bari F, Janovák L. The Effect of Molecular Weight on the Solubility Properties of Biocompatible Poly(ethylene succinate) Polyester. Polymers (Basel). 2021 Aug 15;13(16):2725. doi: 10.3390/polym13162725.
Open access - Francistiová L, Klepe A, Curley G, Gulya K, Dinnyés A, Filkor K. Cellular and Molecular Effects of SARS-CoV-2 Linking Lung Infection to the Brain. Front. Immunol., 2021 Aug 13. doi.org/10.3389/fimmu.2021.730088.
Open access - Szabó Í, Varga VÉ, Dvorácskó S, Farkas AE, Körmöczi T, Berkecz R, Kecskés S, Menyhárt Á, Frank R, Hantosi D, Cozzi NV, Frecska E, Tömböly C, Krizbai IA, Bari F, Farkas E. N,N-Dimethyltryptamine attenuates spreading depolarization and restrains neurodegeneration by sigma-1 receptor activation in the ischemic rat brain. Neuropharmacology. 2021 Jul 1;192:108612. doi: 10.1016/j.neuropharm.2021.108612.
Open access - Pansri P, Phanthong P, Suthprasertporn N, Kitiyanant Y, Tubsuwan A, Dinnyes A, Kobolak J, Kitiyanant N. Brain-derived neurotrophic factor increases cell number of neural progenitor cells derived from human induced pluripotent stem cells. PeerJ. 2021 May 12;9:e11388. doi: 10.7717/peerj.11388. eCollection 2021.
Open access - Frank R, Bari F, Menyhárt Á, Farkas E. Comparative analysis of spreading depolarizations in brain slices exposed to osmotic or metabolic stress. BMC Neurosci. 2021 May 3;22(1):33. doi: 10.1186/s12868-021-00637-0.
Open access - Dulka K, Szabo M, Lajkó N, Belecz I, Hoyk Z, Gulya K. Epigenetic Consequences of in Utero Exposure to Rosuvastatin: Alteration of Histone Methylation Patterns in Newborn Rat Brains. Int J Mol Sci. 2021 Mar 26;22(7):3412. doi: 10.3390/ijms22073412.
Open access - Tóth R, Farkas AE, Krizbai IA, Makra P, Bari F, Farkas E, Menyhárt Á. Astrocyte Ca2+ Waves and Subsequent Non-Synchronized Ca2+ Oscillations Coincide with Arteriole Diameter Changes in Response to Spreading Depolarization. Int J Mol Sci. 2021 Mar 26;22(7):3442. doi: 10.3390/ijms22073442.
Open access - Wang X, Li M, Zhang X, Li Y, He G, Dinnyés A, Sun Q, Xu W. CYP11A1 Upregulation Leads to Trophoblast Oxidative Stress and Fetal Neurodevelopmental Toxicity That can be Rescued by Vitamin D. Front Mol Biosci. 2021 Feb 15;7:608447. doi: 10.3389/fmolb.2020.608447. eCollection 2020.
Open access - Dulka K, Nacsa K, Lajkó N, Gulya K. Quantitative morphometric and cell-type-specific population analysis of microglia-enriched cultures subcloned to high purity from newborn rat brains. IBRO Neurosci Rep. 2021 Feb 6;10:119-129. doi: 10.1016/j.ibneur.2021.01.007. eCollection 2021 Jun.
Open access