Research papers

2025

Kecskés S., Mészáros M., Dvorácskó S., Szabó Í., Porkoláb G., Barna L., Harazin A., Szecskó A., Menyhárt Á., Bari F., Deli MA., Penke B., Farkas E., Veszelka S. (2025) The impact of the novel σ1 receptor ligand (S)-L1 on brain endothelial cells and cerebrovascular reactivity challenged by ischemia. Eur J Pharmacol. doi: doi.org/10.1016/j.ejphar.2025.177724.
Open access

Amin KWK., Deák Á., Farkas E., Rose CR., Bari F., Janovák L., (2025) Hydrophobically modified Chitosan-Pluronic nanocarriers for controlled release of Nimodipine and HC-067047 drugs in ischemic tissues. Mater. Today Chem. Volume 46. doi: doi.org/10.1016/j.mtchem.2025.102743.
Open access

Tóth R., Szabó N., Törteli A., Kovács N., Horváth I., Szigeti K., Máthé D., Kincses TZ., Menyhárt Á., Farkas E. (2025) The paradoxical relationship of sensorimotor deficit and lesion volume in acute ischemic stroke. J Neuropathol Exp Neurol. doi: 10.1093/jnen/nlaf046.
Open access

Pesti I., Varga V., Qorri E., Frank R., Kata D., Vinga K., Szarvas PA., Menyhárt Á., Gulya K., Bari F., Farkas E. (2025). Nimodipine reduces microglial activation in vitro as evidenced by morphological phenotype, phagocytic activity and high-throughput RNA sequencing. Br J Pharmacol. doi: 10.1111/bph.70060.
Open access

2024

Somogyi P., Tóth I., Ballók B., Hammad Z., Hussein R. A., Kun-Szabó F., Tolnai J., Danis J., Kecskés S., Fodor G. H., Farkas E., Peták F. (2024). Pulmonary consequences of experimentally induced stroke: differences between global and focal cerebral ischemia. Front. Physiol. Sec. Respiratory Physiology and Pathophysiology Volume 15. doi: 10.3389/fphys.2024.1511638.
Open access

Farkas E., Rose CR. (2024). A dangerous liaison: Spreading depolarization and tissue acidification in cerebral ischemia. J Cereb Blood Flow Metab. 13:271678X241289756. doi: 10.1177/0271678X241289756.
Open access

Bari F., Péter V., Menyhárt Á., Farkas E. (2024). Potentials and limitations of nanomedicine in the treatment of stroke patients. Orv Hetil. 165(36):1403-1410. doi: 10.1556/650.2024.33116.
Open access

Törteli A., Tóth R., Bari F., Farkas E., Menyhárt Á. (2024). Collateral is brain: Low perfusion triggers spreading depolarization and futile reperfusion after acute ischemic stroke. J Cereb Blood Flow Metab. 3:271678X241270480. doi: 10.1177/0271678X241270480.
Open access

Pesti, I., Barczánfalvi, G., Dulka, K., Kata, D., Farkas, E., & Gulya, K. (2024). Bafilomycin 1A Affects p62/SQSTM1 Autophagy Marker Protein Level and Autophagosome Puncta Formation Oppositely under Various Inflammatory Conditions in Cultured Rat Microglial Cells. Int J Mol Sci. 25(15):8265. doi: 10.3390/ijms25158265.
Open access

Ali, Z., Frank, R., Körmöczi, T., Ilisz, I., Domoki, F., Weizner, R., Bari F., Farkas, E., & Berkecz, R. (2024). UHPLC-MS/MS Approach for Following Nimodipine Saturation Kinetics in Acute Rat Brain Slice. J. Anal. Test. doi: 10.1007/s41664-024-00316-z.
Open access

Frank, R., Szarvas, P. A., Pesti, I., Zsigmond, A., Berkecz, R., Menyhárt, Á., Bari, F., & Farkas, E. (2024). Nimodipine inhibits spreading depolarization, ischemic injury, and neuroinflammation in mouse live brain slice preparations. Eur J Pharmacol. 977:176718. doi: 10.1016/j.ejphar.2024.176718.
Open access

Pesti, I., Légrádi, Á., & Farkas, E. (2024). Primary microglia cell cultures in translational research: Strengths and limitations. J Biotechnol. 386:10-18. doi: 10.1016/j.jbiotec.2024.03.005.
Open access

Dulka K, Lajkó N, Nacsa K, Gulya K. (2024) Opposite and Differently Altered Postmortem Changes in H3 and H3K9me3 Patterns in the Rat Frontal Cortex and Hippocampus. Epigenomes. 8(1):11. doi: 10.3390/epigenomes8010011.
Open access

Menyhárt, Á., Bálint, A. R., Kozák, P., Bari, F., & Farkas, E. (2024). Nimodipine accelerates the restoration of functional hyperemia during spreading oligemia. J Neurochem. 168(5):888-898. doi: 10.1111/jnc.15792.
Open access

2023

Zhou Z, Wang D, Luo D, Zhou Z, Liu W, Zeng W, Dinnyés A, Xiong YL, Sun Q. (2023) Non-covalent binding of chlorogenic acid to myofibrillar protein improved its bio-functionality properties and metabolic fate. Food Chem. 440:138208. doi: 10.1016/j.foodchem.2023.138208.
Open access

Farkas, E., Frank, R., Menyhárt, Á. (2023) The contribution of astrocytes to ischemia-related cerebral edema formation and increased neuronal excitability. Glia. 71(S1), pp. E92. doi: 10.1002/glia.24417.
Open access

Frank, R., Farkas, E., Menyhárt, Á. (2023) The role of astrocyte dysfunction in the evolution of spreading depolarization during ischemia. Glia. 71(S1), pp. E669. doi: 10.1002/glia.24417.
Open access

Frank, R., Pesti, I. Menyhárt, Á., Szarvas, P., Gulya, K., Bari, F., Farkas, E. (2023) Nimodipine exerts a protective effect against spreading depolarization and neuroinflammation. Physiology. 38(S1). doi: 10.1152/physiol.2023.38.S1.5762940.
Open access

Törteli, A., Bálint, A.R., Tóth, R., Makra, P., Bari, F., Farkas, E., Menyhárt, Á. (2023) Reperfusion failure after spreading depolarization shapes hemoglobin content in the mouse cortex. IBRO Neuroscience Reports. 15, S467-S867, P1300 / #4102. doi: 10.1016/j.ibneur.2023.08.1306.
Open access

Tóth, R., Kovács, N., Horváth, I., Máthé, D., Menyhárt, Á., Farkas, E. (2023) Infarct size in the subacute phase of experimental focal ischemic stroke does not correspond with functional outcomes. J. Cereb. Blood Flow Metab. 43(1S), S122. doi: 10.1177/0271678X231176482.
Open acccess

Bari, F., Bálint, A.R., Menyhárt, Á., Farkas, E. (2023) Spreading depolarization impairs neurovascular coupling in ischemia/reperfusion in mice. J. Cereb. Blood Flow Metab. 43(1S), S30. doi: 10.1177/0271678X231176478.
Open acccess

Ballók B, Schranc Á, Tóth I, Somogyi P, Tolnai J, Peták F, Fodor GH. (2023) Comparison of the respiratory effects of commonly utilized general anaesthesia regimes in male Sprague-Dawley rats. Front Physiol. 14:1249127. doi: 10.3389/fphys.2023.1249127.
Open access

Horánszky A, Shashikadze B, Elkhateib R, Lombardo SD, Lamberto F, Zana M, Menche J, Fröhlich T, Dinnyés A. (2023) Proteomics and disease network associations evaluation of environmentally relevant Bisphenol A concentrations in a human 3D neural stem cell model. Front Cell Dev Biol. 11:1236243. doi: 10.3389/fcell.2023.1236243.
Open access

Lamberto F, Shashikadze B, Elkhateib R, Lombardo SD, Horánszky A, Balogh A, Kistamás K, Zana M, Menche J, Fröhlich T, Dinnyés A. (2023) Low-dose Bisphenol A exposure alters the functionality and cellular environment in a human cardiomyocyte model. Environ Pollut. 335:122359. doi: 10.1016/j.envpol.2023.122359.
Open Access

Kiss T, Mir Y, Stefancsik G, Ganbat G, Askarova A, Monostori E, Dulka K, Szebeni GJ, Nyúl-Tóth Á, Csiszár A, Legradi A. (2023) Galectin-1 as a marker for microglia activation in the aging brain. Brain Res. 1818:148517. doi: 10.1016/j.brainres.2023.148517.
Open Access

Kistamás K, Müller A, Muenthaisong S, Lamberto F, Zana M, Dulac M, Leal F, Maziz A, Costa P, Bernotiene E, Bergaud C, Dinnyés A. (2023) Multifactorial approaches to enhance maturation of human iPSC-derived cardiomyocytes. J. Mol. Liq. 387:122668. doi: 10.1016/j.molliq.2023.122668.
Open Access

Szabo M, Lajkó N, Dulka K, Barczánfalvi G, Lőrinczi B, Szatmári I, Mihály A, Vécsei L, Gulya K. (2023) The kynurenic acid analog SZR104 induces cytomorphological changes associated with the anti-inflammatory phenotype in cultured microglia. Sci Rep. 13(1):11328. doi: 10.1038/s41598-023-38107-8.
Open access

Zhou Z, Luo D, Li M, Lao G, Zhou Z, Dinnyés A, Xu W, Sun Q. (2023) A Novel Multicellular Placental Barrier Model to Investigate the Effect of Maternal Aflatoxin B1 Exposure on Fetal-Side Neural Stem Cells. Toxins (Basel). 15(5):312. doi: 10.3390/toxins15050312.
Open access

Kecskés, Sz.,Menyhárt, Á., Bari, F., Farkas, E. (2023) Nimodipine augments cerebrovascular reactivity in aging but runs the risk of local perfusion reduction in acute cerebral ischemia. Front Aging Neurosci. 15:1175281. doi: 10.3389/fnagi.2023.1175281.
Open access

Törteli, A., Tóth, R., Berger, S., Samardzic, S., Bari, F., Menyhárt, Á., & Farkas, E. (2023). Spreading depolarization causes reperfusion failure after cerebral ischemia. J Cereb Blood Flow Metab. 43(5):655-664. doi: 10.1177/0271678X231153745.
Open access

Zhou, Z., Wang, D., Xu, X., Dai, J., Lao, G., Zhang, S., Xu, X., Dinnyés, A., Xiong, Y., & Sun, Q. (2023). Myofibrillar protein-chlorogenic acid complexes ameliorate glucose metabolism via modulating gut microbiota in a type 2 diabetic rat model. Food Chem. 409:135195. doi: 10.1016/j.foodchem.2022.135195.
Open access

2022

Hojeij, B., Rousian, M., Sinclair, K. D., Dinnyes, A., Steegers-Theunissen, R. P. M., & Schoenmakers, S. (2022). Periconceptional biomarkers for maternal obesity: a systematic review. Reviews in Endocrine &Rev Endocr Metab Disord. 24(2):139-175. doi: 10.1007/s11154-022-09762-5.
Open access

Tian, L., Zhao, R., Xu, X., Zhou, Z., Xu, X., Luo, D., Zhou, Z., Liu, Y., Kushmaro, A., Marks, R. S., Dinnyés, A., & Sun, Q. (2022). Modulatory effects of Lactiplantibacillus plantarum on chronic metabolic diseases. Food Science and Human Wellness. 12(4), 959–974. doi: 10.1016/j.fshw.2022.10.018.
Open access

Kovács T, Szinyákovics J, Billes V, Murányi G, Varga VB, Bjelik A, Légrádi Á, Szabó M, Sándor S, Kubinyi E, Szekeres-Paracky C, Szocsics P, Lőke J, Mulder J, Gulyás B, Renner É, Palkovits M, Gulya K, Maglóczky Z, Vellai T. (2022) A conserved MTMR lipid phosphatase increasingly suppresses autophagy in brain neurons during aging. Sci Rep. 12(1):21817. doi: 10.1038/s41598-022-24843-w.
Open access

Kata D, Gróf I, Hoyk Z, Ducza E, Deli MA, Zupkó I, Földesi I. (2022) Immunofluorescent Evidence for Nuclear Localization of Aromatase in Astrocytes in the Rat Central Nervous System. Int J Mol Sci. 23(16):8946. doi: 10.3390/ijms23168946.
Open access

Fehér A, Schnúr A, Muenthaisong S, Bellák T, Ayaydin F, Várady G, Kemter E, Wolf E, Dinnyés A. (2022) Establishment and characterization of a novel human induced pluripotent stem cell line stably expressing the iRFP720 reporter. Sci Rep. 12(1):9874. doi: 10.1038/s41598-022-12956-1.
Open access

Menyhárt Á, Frank R, Farkas AE, Süle Z, Varga VÉ, Nyúl-Tóth Á, Meiller A, Ivánkovits-Kiss O, Lemale CL, Szabó Í, Tóth R, Zölei-Szénási D, Woitzik J, Marinesco S, Krizbai IA, Bari F, Dreier JP, Farkas E. (2022) Malignant astrocyte swelling and impaired glutamate clearance drive the expansion of injurious spreading depolarization foci. J Cereb Blood Flow Metab. 42(4):584-599. doi: 10.1177/0271678X211040056.
Open access

Abdelghafour MM, Orbán Á, Deák Á, Lamch Ł, Frank É, Nagy R, Ziegenheim S, Sipos P, Farkas E, Bari F, Janovák L. (2022) Biocompatible poly(ethylene succinate) polyester with molecular weight dependent drug release properties. Int J Pharm. 618:121653. doi: 10.1016/j.ijpharm.2022.121653.
Open access

Andrew RD, Hartings JA, Ayata C, Brennan KC, Dawson-Scully KD, Farkas E, Herreras O, Kirov SA, Müller M, Ollen-Bittle N, Reiffurth C, Revah O, Robertson RM, Shuttleworth CW, Ullah G, Dreier JP. (2022) The Critical Role of Spreading Depolarizations in Early Brain Injury: Consensus and Contention. Neurocrit Care. 37(Suppl 1):83-101. doi: 10.1007/s12028-021-01431-w.
Open access

Császár E, Lénárt N, Cserép C, Környei Z, Fekete R, Pósfai B, Balázsfi D, Hangya B, Schwarcz AD, Szabadits E, Szöllősi D, Szigeti K, Máthé D, West BL, Sviatkó K, Brás AR, Mariani JC, Kliewer A, Lenkei Z, Hricisák L, Benyó Z, Baranyi M, Sperlágh B, Menyhárt Á, Farkas E, Dénes Á. (2022) Microglia modulate blood flow, neurovascular coupling, and hypoperfusion via purinergic actions. J Exp Med. 219(3):e20211071. doi: 10.1084/jem.20211071.
Open access

Andrew RD, Farkas E, Hartings JA, Brennan KC, Herreras O, Müller M, Kirov SA, Ayata C, Ollen-Bittle N, Reiffurth C, Revah O, Robertson RM, Dawson-Scully KD, Ullah G, Dreier JP. (2022) Questioning Glutamate Excitotoxicity in Acute Brain Damage: The Importance of Spreading Depolarization. Neurocrit Care. 37(Suppl 1):11-30. doi: 10.1007/s12028-021-01429-4.
Open access

Nunes C, Singh P, Mazidi Z, Murphy C, Bourguignon A, Wellens S, Chandrasekaran V, Ghosh S, Zana M, Pamies D, Thomas A, Verfaillie C, Culot M, Dinnyes A, Hardy B, Wilmes A, Jennings P, Grillari R, Grillari J, Zurich MG, Exner T. (2022) An in vitro strategy using multiple human induced pluripotent stem cell-derived models to assess the toxicity of chemicals: A case study on paraquat. Toxicol In Vitro. 81:105333. doi: 10.1016/j.tiv.2022.105333.
Open access

Szabo M, Lajkó N, Dulka K, Szatmári I, Fülöp F, Mihály A, Vécsei L, Gulya K. (2022) Kynurenic Acid and Its Analog SZR104 Exhibit Strong Antiinflammatory Effects and Alter the Intracellular Distribution and Methylation Patterns of H3 Histones in Immunochallenged Microglia-Enriched Cultures of Newborn Rat Brains. Int J Mol Sci. 23(3):1079. doi: 10.3390/ijms23031079.
Open access

Mitrečić D, Hribljan V, Jagečić D, Isaković J, Lamberto F, Horánszky A, Zana M, Foldes G, Zavan B, Pivoriūnas A, Martinez S, Mazzini L, Radenovic L, Milasin J, Chachques JC, Buzanska L, Song MS, Dinnyés A. (2022) Regenerative Neurology and Regenerative Cardiology: Shared Hurdles and Achievements. Int J Mol Sci. 23(2):855. doi: 10.3390/ijms23020855.
Open access

Francistiová L, Vörös K, Lovász Zs, Dinnyés A, and Kobolák J. (2022) Detection and Functional Evaluation of the P2X7 Receptor in HiPSC Derived Neurons and Microglia-Like Cells. Front Mol Neurosci. 14:793769. doi: 10.3389/fnmol.2021.793769.
Open access

Menyhárt Á, Varga DP, M Tóth O, Makra P, Bari F, Farkas E. (2022) Transient Hypoperfusion to Ischemic/Anoxic Spreading Depolarization is Related to Autoregulatory Failure in the Rat Cerebral Cortex. Neurocrit Care. 37(Suppl 1):112-122. doi: 10.1007/s12028-021-01393-z.
Open access

2021

Horánszky A, Becker JL, Zana M, Ferguson-Smith AC, Dinnyés A. (2021) Epigenetic Mechanisms of ART-Related Imprinting Disorders: Lessons From iPSC and Mouse Models. Genes (Basel). 12(11):1704. doi: 10.3390/genes12111704.
Open access

Rubini E, Baijens IMM, Horánszky A, Schoenmakers S, Sinclair KD, Zana M, Dinnyés A, (2021) Steegers-Theunissen RPM, Rousian M. Maternal One-Carbon Metabolism during the Periconceptional Period and Human Foetal Brain Growth: A Systematic Review. Genes (Basel). 12(10):1634. doi: 10.3390/genes12101634.;
Open access

Lamberto F, Peral-Sanchez I, Muenthaisong S, Zana M, Willaime-Morawek S, Dinnyés A. (2021) Environmental Alterations during Embryonic Development: Studying the Impact of Stressors on Pluripotent Stem Cell-Derived Cardiomyocytes. Genes (Basel). 12(10):1564. doi: 10.3390/genes12101564.
Open access

Abdelghafour MM, Orbán Á, Deák Á, Lamch Ł, Frank É, Nagy R, Ádám A, Sipos P, Farkas E, Bari F, Janovák L. (2021) The Effect of Molecular Weight on the Solubility Properties of Biocompatible Poly(ethylene succinate) Polyester. Polymers (Basel). 13(16):2725. doi: 10.3390/polym13162725.
Open access

Francistiová L, Klepe A, Curley G, Gulya K, Dinnyés A, Filkor K. (2021) Cellular and Molecular Effects of SARS-CoV-2 Linking Lung Infection to the Brain. Front Immunol. 12:730088. doi: 10.3389/fimmu.2021.730088.
Open access

Szabó Í, Varga VÉ, Dvorácskó S, Farkas AE, Körmöczi T, Berkecz R, Kecskés S, Menyhárt Á, Frank R, Hantosi D, Cozzi NV, Frecska E, Tömböly C, Krizbai IA, Bari F, Farkas E. (2021) N,N-Dimethyltryptamine attenuates spreading depolarization and restrains neurodegeneration by sigma-1 receptor activation in the ischemic rat brain. Neuropharmacology. 192:108612. doi: 10.1016/j.neuropharm.2021.108612.
Open access

Pansri P, Phanthong P, Suthprasertporn N, Kitiyanant Y, Tubsuwan A, Dinnyes A, Kobolak J, Kitiyanant N. (2021) Brain-derived neurotrophic factor increases cell number of neural progenitor cells derived from human induced pluripotent stem cells. PeerJ. 9:e11388. doi: 10.7717/peerj.11388.
Open access

Frank R, Bari F, Menyhárt Á, Farkas E. (2021) Comparative analysis of spreading depolarizations in brain slices exposed to osmotic or metabolic stress. BMC Neurosci. 22(1):33. doi: 10.1186/s12868-021-00637-0.
Open access

Dulka K, Szabo M, Lajkó N, Belecz I, Hoyk Z, Gulya K. (2021) Epigenetic Consequences of in Utero Exposure to Rosuvastatin: Alteration of Histone Methylation Patterns in Newborn Rat Brains. Int J Mol Sci. 22(7):3412. doi: 10.3390/ijms22073412.
Open access

Tóth R, Farkas AE, Krizbai IA, Makra P, Bari F, Farkas E, Menyhárt Á. (2021) Astrocyte Ca2+ Waves and Subsequent Non-Synchronized Ca2+ Oscillations Coincide with Arteriole Diameter Changes in Response to Spreading Depolarization. Int J Mol Sci. 22(7):3442. doi: 10.3390/ijms22073442.
Open access

Wang X, Li M, Zhang X, Li Y, He G, Dinnyés A, Sun Q, Xu W. (2021) CYP11A1 Upregulation Leads to Trophoblast Oxidative Stress and Fetal Neurodevelopmental Toxicity That can be Rescued by Vitamin D. Front Mol Biosci. 7:608447. doi: 10.3389/fmolb.2020.608447.
Open access